Orthosiphon stamineus Benth (Uses and Bioactivities)

Marina Silalahi


Orthosiphon stamineus Benth., or kumis kucing is a the medicinal plants have been used as diuretic medicine. The utilization of medicinal plants associated to its secondary metabolite. This article aims to explain uses pf the O. stamineus and the its secondary metabolites. This article is based on literature offline and online media. Offline literature used the books, whereas online media used Web, Scopus, Pubmed, and scientific journals. Orthosiphon stamineus has two varieties called purple varieties (which have purple-colored flowers) and white varieties (which have white-colored flowers). Some of secondary metabolites in the O. stamineus are the terpenoids, phenols, isopimaran type ispenimoids, flavonoids, benzochromes, and organic acid derivatives. The traditional medicine of the Orthosiphon stamineus uses as the diuretic, hypertension, hepatitis, jaundice, and diabetes mellitus.


Keywords: Orthosiphon stamineus, diuretics, diterpenoids, hypertension


Full Text:



Abdullah, S., Shaari, A.R., & Azimi. A. (2012). Effect of drying methods on metabolites composition of misai kucing (Orthosiphon stamineus) Leaves ICBFS 2012: April 7-8, 2012, Bangkok, Thailand. APCBEE Procedia 2:178-182.

Achmad, S.J., Y.M. Syah, E.H. Hakim, L.D. Juliawaty, L.makmur, & D. Mujahidin. (2008). Ilmu kimia dan kegunaan tumbuh-tumbuhan obat Indonesia. Institut Teknologi Bandung: Bandung.

Almatar, M., Rahmat, Z. & Salle, F.M. (2013). Preliminary morphological and anatomical study of Orthosiphon stamineus Indian. J.Pharm.Biol.Res., 1(4): 1-6

Alshawsh, M.A., Abdulla, M.A., Ismail, S. & Amin, Z,A. (2011). Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats. Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 103039, 6 pages doi:10.1155/2011/103039

Azam, A.A., Pariyani, R., Ismail, I.S., Ismail, A., Khatib, A., Abas, F. & Shaari, K. (2017). Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats via 1H NMR spectroscopy BMC Complementary and Alternative Medicine, 17:278 DOI 10.1186/s12906-017-1777-1

Congruist, A. (1981). An intergrated system of classification of flowering plants.Colmbia University Press, New York hlm 924-927

Galato, D., Ckless, K., Susin, M.F., Giacomelli, C., & Spinelli, A. (2001). antioxidant capacity of phenolic and related compounds: correlation among electrochemical, visible spectroscopy methods and structure-antioxidant activity. Redox Rep., 6: 243-250.

Hossain, M.A. & Rahman, S.M.M. (2015). Isolation and characterisation of flavonoids from the leaves of medicinal plant Orthosiphon stamineus. Arabian Journal of Chemistry 8: 218–221.

Indubala, J. & Ng, L. (2000). Herbs: The Green Pharmacy of Malaysia, Vinpress Sdn Bhd, Kuala Lumpur, Malaysia.

IDF. (2014). International diabetes federation. diabetes atlas. 5th ed. brussels: international diabetes federation.

Joel, G.H., & Lee, E.L. (2001) Goodman and Gilman, the Pharmacological Basis of Therapeutics, 10th ed.; McGraw-Hill: New York, NY: 1679-1698.

Keng, C.L. & Siong, L.P. (2006). Morphological similarities and differences between the two varieties of cat’s whiskers (Orthosiphon stamineus Benth.) grown in Malaysia. Int. J. Bot., 2: 1-6.

Lee, H.J., Choi, Y.J., Park, S.Y., Kim, J.Y., Won, K.C., Son, J.K. & Kim, Y.W. (2015). Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells. Diabetes Metab. J., 39: 51-58.

Lee. W.L. (2004). Micropropagation and cell culture of misai kucing (Orthosiphon stamineus Benth) and detection of rosmarinic acid in te in Vitro cultures. MSc. Thesis, Universiti Sains Malaysia, Penang, Malaysia.

Manshor, N.M,, Dewa, A., Asmawi, M.Z., Ismail, Z., Razali, N. & Hassan, Z. (2013). Vascular reactivity concerning Orthosiphon stamineus Benth mediated antihypertensive in aortic rings of spontaneously hypertensive rats. Hindawi Publishing Corporation International Journal of Vascular Medicine Volume 2013, Article ID 456852, 8 pages http://dx.doi.org/10.1155/2013/456852

Mariam, A., Asmawi, M.Z., & Sadikun, A. (1996). Hypoglycaemic activity of the aqueous extract of Orthosiphon stamineus. Fitoterapia LXVII: 465-468.

Mohamed, E.A.H., Yam, M.F., Ang, L.F., Mohamed, A.J. & Asmawi, M.A. (2013). Antidiabetic properties and mechanism of action of Orthosiphon stamineus Benth bioactive sub-fraction in streptozotocin-induced diabetic rats. J. Acupunct. Meridian Stud., 6(1): 31-40

Sadashiva, C.T., Sharanappa, P., Naidoo, Y., Sulaimon, C.T. & Balachandran, I. (2013). Chemical composition of essential oil from Orthosiphon diffuses Benth. J. Med. Plants Res., 7: 170-172.

Schwarz, P.E.H., Gallein, G., Ebermann, D., Müller, A., Lindner, A., Rothe, U. & Müller, G. (2013). Global diabetes survey an annual report on quality of diabetes care. Diabetes Res Clin Pract., 100: 11-8.

Singh, M.K., Gidwani, B., Gupta, A., Dhongade, H., Kaur, C.D., Kashyap, P.P. & Tripathi, D.K. (2015). A review of the medicinal plants of Genus Orthosiphon (Lamiaceae). International Journal of Biological Chemistry 9 (6): 318-331, 2015 ISSN 1819-155X / DOI: 10.3923/ijbc.2015.318.331

Taiz L. dan Zeiger E. (2006). Plant Physiology. Sinauer Associates, Inc, Sunderland

Tong, W.Y., Darah, I. & Latiffah, Z. (2011). Antimicrobial activities of endophytic fungal isolates from medicinal herb Orthosiphon stamineus Benth. Journal of Medicinal Plants Research, 5(5): 831-836.

Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004). Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 27:1047–53.

Willcox, J., Sarah, A., & Catignani, G. (2004). Antioxidants and prevention of chronic disease. Crit. Rev. Food Sci. Nutr., 44: 275–295.

Yam, M.F., Mohamed, E.A.H., Ang, L.F., Pei, L., Darwis, Y., Mahmud, R., Asmawi, M.Z., Basir, R. & Ahmad, M. (2012). A simple isocratic HPLC method for the simultaneous determination of sinensetin, eupatorin, and 30-hydroxy-5,6,7, 40-tetramethoxyflavone in Orthosiphon stamineus extracts. Journal Acupunct. Meridian Stud., 5(4): 176-181.

DOI: 10.31002/ijose.v3i1.729

Article Metrics

Abstract view : 16 times
PDF - 0 times


  • There are currently no refbacks.

Copyright (c) 2019

 Creative Commons License
Indonesian Journal of Science and Education is licensed under a Creative Commons Attribution 4.0 International License.Copyright © Universitas Tidar. All rights reserved. p-ISSN2598-5213, e-ISSN 2598-5205  View my Stat